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J Biol Chem 2017;292:14240-9

Ferroptosis and Its Potential Role in Human Diseases

Literature suggests that effective modulation of energy metabolism and insulin signaling through the regulation of AMP-activated protein kinase (AMPK) or phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathways appears to reverse some devastating outcomes of diabetes (Long and Zierath, 2006